Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1- and G6PC-mediated gluconeogenesis

• Main Authors: Hanyu Yang (Author), Mengxiang Su (Author), Ming Liu (Author), Yun Sheng (Author), Liang Zhu (Author), Lu Yang (Author), Ruijing Mu (Author), Jianjun Zou (Author), Xiaodong Liu (Author), Li Liu (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Type 2 diabetes (T2D) is often accompanied with an induction of retinaldehyde dehydrogenase 1 (RALDH1 or ALDH1A1) expression and a consequent decrease in hepatic retinaldehyde (Rald) levels. However, the role of hepatic Rald deficiency in T2D progression remains unclear. In this study, we demonstrat...