Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1- and G6PC-mediated gluconeogenesis

• मुख्य लेखकों: Hanyu Yang (लेखक), Mengxiang Su (लेखक), Ming Liu (लेखक), Yun Sheng (लेखक), Liang Zhu (लेखक), Lu Yang (लेखक), Ruijing Mu (लेखक), Jianjun Zou (लेखक), Xiaodong Liu (लेखक), Li Liu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Type 2 diabetes (T2D) is often accompanied with an induction of retinaldehyde dehydrogenase 1 (RALDH1 or ALDH1A1) expression and a consequent decrease in hepatic retinaldehyde (Rald) levels. However, the role of hepatic Rald deficiency in T2D progression remains unclear. In this study, we demonstrat...