Characterization and in vitro release studies of oral microbeads containing thiolated pectin-doxorubicin conjugates for colorectal cancer treatment

• Главные авторы: Kamonrak Cheewatanakornkool (Автор), Sathit Niratisai (Автор), Somkamol Manchun (Автор), Crispin R. Dass (Автор), Pornsak Sriamornsak (Автор)
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• Опубликовано: Elsevier, 2017-11-01T00:00:00Z.
• Предметы: article
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Novel oral microbeads were developed based on a biopolymer-drug conjugate of doxorubicin (DOX) conjugated with thiolated pectin via reducible disulfide bonds. The microbeads were fabricated by ionotropic gelation with cations such as Al3+, Ca2+ and Zn2+. The results showed that using zinc acetate ca...