Model‐informed assessment of ethnic sensitivity and dosage justification for Asian populations in the global clinical development and use of cladribine tablets

• Egile Nagusiak: Alain Munafo (Egilea), Nadia Terranova (Egilea), Dandan Li (Egilea), Ping Liu (Egilea), Karthik Venkatakrishnan (Egilea)
• Formatua: Liburua
• Argitaratua: Wiley, 2022-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Cladribine tablets have been approved in many countries for the treatment of patients with various forms of relapsing multiple sclerosis (MS). Cladribine has a unique pharmacokinetic/pharmacodynamic (PK/PD) profile with a short elimination half‐life (~ 1 day) relative to a prolonged PD effe...