Assessment of CYP‐Mediated Drug Interactions for Evocalcet, a New Calcimimetic Agent, Based on In Vitro Investigations and a Cocktail Study in Humans

• Asıl Yazarlar: Kazuya Narushima (Yazar), Hiroshi Maeda (Yazar), Masanari Shiramoto (Yazar), Yuichi Endo (Yazar), Satoko Ohtsuka (Yazar), Hiroaki Nakamura (Yazar), Yoshinori Nagata (Yazar), Tatsuo Uchimura (Yazar), Ayako Kannami (Yazar), Ryutaro Shimazaki (Yazar), Masafumi Fukagawa (Yazar), Tadao Akizawa (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2019-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Evocalcet is a novel calcimimetic agent for the treatment of secondary hyperparathyroidism (SHPT). This study evaluated the effects of evocalcet on inhibition and induction of cytochrome P450 (CYP) isozymes. Although drug interactions arising from reversible inhibition of CYP isozymes by ev...