A novel mechanism of 6-methoxydihydroavicine in suppressing ovarian carcinoma by disrupting mitochondrial homeostasis and triggering ROS/ MAPK mediated apoptosis

• Main Authors: Huachang Zhang (Author), Fugen Shangguan (Author), Lan Zhang (Author), Nengfang Ma (Author), Shuling Song (Author), Li Ma (Author), Chuntong Liu (Author), Mengke Liu (Author), Jing An (Author), Hua Li (Author), Qizhi Cao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Alkaloids derived from M. cordata (Papaveraceae family), have been found to display antineoplastic activity in several types of cancer. However, the antitumor effects and mechanisms of a new alkaloid extracted from the fruits of M. cordata, named 6-Methoxydihydroavicine (6-ME), remains...