Development and Characterization of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology

• Váldodahkkit: Abdullah Alshetaili (Dahkki), Bjad K. Almutairy (Dahkki), Sultan M. Alshehri (Dahkki), Michael A. Repka (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2021-02-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers. Hydrophobic carriers with different physicochemical properties such as pH-independent swell...