Growth Hormone-Releaser Diet Attenuates β-Amyloid(1-42)-Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice

• Main Authors: Eun-Joo Shin (Author), Jong Seok Chae (Author), Seok Joo Park (Author), Sun Cheol Kim (Author), Kyo Hwan Koo (Author), Kiyofumi Yamada (Author), Toshitaka Nabeshima (Author), Hyoung-Chun Kim (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously demonstrated that the growth hormone (GH)-releaser diet ameliorated β-amyloid (Aβ) (1-42)-induced memory impairment, but the underlying mechanism remained to be characterized. We show here that the GH-releaser diet significantly attenuated Aβ(1-42)-induced impairment in context-depende...