Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells

• Main Authors: Lawrence J. Billing (Author), Christopher A. Smith (Author), Pierre Larraufie (Author), Deborah A. Goldspink (Author), Sam Galvin (Author), Richard G. Kay (Author), Jonathan D. Howe (Author), Ryan Walker (Author), Mihai Pruna (Author), Leslie Glass (Author), Ramona Pais (Author), Fiona M. Gribble (Author), Frank Reimann (Author)
• Format: Book
• Published: Elsevier, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin-like peptide-5 (INSL5) is an orexigenic gut hormone found in a subset of colonic and rectal enteroendocrine L-cells together with the anorexigenic hormones glucagon-like peptide-1 (GLP-1) and peptideYY (PYY). Unlike GLP-1 and PYY, INSL5 levels are elevated by calorie restriction,...