Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors

• Հիմնական հեղինակներ: Özlen Güzel-Akdemir (Հեղինակ), Andrea Angeli (Հեղինակ), Kübra Demir (Հեղինակ), Claudiu T. Supuran (Հեղինակ), Atilla Akdemir (Հեղինակ)
• Ձևաչափ: Գիրք
• Հրապարակվել է: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Խորագրեր: article
• Առցանց հասանելիություն: Connect to this object online.

A small collection of 26 structurally novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group, were synthesised and tested in enzyme inhibition assays against the tumour-associated hCA IX enzyme. Inhibition constants in the lower micromolar region (KI < 2...