Inhibition of ACOX1 enhances the therapeutic efficacy of obeticholic acid in treating non-alcoholic fatty liver disease and mitigates its lipotoxicity

• المؤلفون الرئيسيون: Yuping Yang (مؤلف), Weinan Yuan (مؤلف), Kun He (مؤلف), Chuangzhen Lin (مؤلف), Shenshen Du (مؤلف), Yanqi Kou (مؤلف), Biao Nie (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background and aims:High-dose Obeticholic acid exhibits promise for non-alcoholic fatty liver disease (NAFLD) treatment but can induce lipotoxicity. Our study sought to understand this mechanism and propose a solution.Approach and Results:In a non-alcoholic fatty liver disease (NAFLD) model induced...