Inhibition of ACOX1 enhances the therapeutic efficacy of obeticholic acid in treating non-alcoholic fatty liver disease and mitigates its lipotoxicity

• Main Authors: Yuping Yang (Author), Weinan Yuan (Author), Kun He (Author), Chuangzhen Lin (Author), Shenshen Du (Author), Yanqi Kou (Author), Biao Nie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and aims:High-dose Obeticholic acid exhibits promise for non-alcoholic fatty liver disease (NAFLD) treatment but can induce lipotoxicity. Our study sought to understand this mechanism and propose a solution.Approach and Results:In a non-alcoholic fatty liver disease (NAFLD) model induced...