In vivo antiviral efficacy of LCTG-002, a pooled, purified human milk secretory IgA product, against SARS-CoV-2 in a murine model of COVID-19

• Main Authors: Viraj Mane (Author), Rikin Mehta (Author), Nadine Alvarez (Author), Vijeta Sharma (Author), Steven Park (Author), Alisa Fox (Author), Claire DeCarlo (Author), Xiaoqi Yang (Author), David S. Perlin (Author), Rebecca L. R. Powell (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTImmunoglobulin A (IgA) is the most abundant antibody (Ab) in human mucosae, with secretory form (sIgA) being dominant and uniquely stable. sIgA is challenging to produce recombinantly but is naturally found in human milk, which could be considered a global resource for this biologic, justify...