Unique TTC repeat base pair loss mutation in cases of pure neural leprosy: A survival strategy of Mycobacterium leprae?

• Main Authors: Abhishek De (Author), Abu Hena Hasanoor Reja (Author), Supratik Biswas (Author), Basudev Bhattacharya (Author), Gobinda Chatterjee (Author), Keya Basu (Author), Aarti Sarda (Author), Nidhi Chowdhury (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Genomic reduction helps obligate intracellular microbes to survive difficult host niches. Adaptation of Mycobacterium leprae in cases of pure neural leprosy (PNL) in the intracellular niche of peripheral nerves can be associated with some gene loss. Recently, a stable but variable number...