Diverticular Disease Worsening Is Associated with Increased Oxidative Stress and Gut Permeability: New Insights by Circulating Biomarkers

• Main Authors: Lucia Pallotta (Author), Vittoria Cammisotto (Author), Valentina Castellani (Author), Alessia Gioia (Author), Margherita Spigaroli (Author), Dominga Carlomagno (Author), Simona Bartimoccia (Author), Cristina Nocella (Author), Martina Cappelletti (Author), Stefano Pontone (Author), Roberto Carnevale (Author), Francesco Violi (Author), Rosa Vona (Author), Carla Giordano (Author), Pasquale Pignatelli (Author), Carola Severi (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diverticular disease (DD) management is impaired by its pathogenesis, which is still not completely defined, with an unmet clinical need for improved therapies. Ex vivo DD human models demonstrated the presence of a transmural oxidative imbalance that supports an ischemic pathogenesis. This study ai...