Exosomal DNA Aptamer Targeting α-Synuclein Aggregates Reduced Neuropathological Deficits in a Mouse Parkinson's Disease Model

• Main Authors: Xiaoxi Ren (Author), Yun Zhao (Author), Fenqin Xue (Author), Yan Zheng (Author), Haixia Huang (Author), Wei Wang (Author), Yongchang Chang (Author), Hui Yang (Author), Jianliang Zhang (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The α-synuclein aggregates are the main component of Lewy bodies in Parkinson's disease (PD) brain, and they showed immunotherapy could be employed to alleviate α-synuclein aggregate pathology in PD. Recently we have generated DNA aptamers that specifically recognize α-synuclein. In this study,...