Exosomal DNA Aptamer Targeting α-Synuclein Aggregates Reduced Neuropathological Deficits in a Mouse Parkinson's Disease Model

• Hauptverfasser: Xiaoxi Ren (Verfasst von), Yun Zhao (Verfasst von), Fenqin Xue (Verfasst von), Yan Zheng (Verfasst von), Haixia Huang (Verfasst von), Wei Wang (Verfasst von), Yongchang Chang (Verfasst von), Hui Yang (Verfasst von), Jianliang Zhang (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2019-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

The α-synuclein aggregates are the main component of Lewy bodies in Parkinson's disease (PD) brain, and they showed immunotherapy could be employed to alleviate α-synuclein aggregate pathology in PD. Recently we have generated DNA aptamers that specifically recognize α-synuclein. In this study,...