Pregabalin-Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats

• Main Authors: Nariman Essmat (Author), Anna Rita Galambos (Author), Péter P. Lakatos (Author), Dávid Árpád Karádi (Author), Amir Mohammadzadeh (Author), Sarah Kadhim Abbood (Author), Orsolya Geda (Author), Rudolf Laufer (Author), Kornél Király (Author), Pál Riba (Author), Zoltán S. Zádori (Author), Éva Szökő (Author), Tamás Tábi (Author), Mahmoud Al-Khrasani (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel agents or combination-based analgesic therapies are needed. Herein, oral tolperisone, pregabalin, and duloxetine were tested for their antinociceptive effect against rat partial sciatic nerve ligation (pSNL)...