Salidroside Inhibits CCl4-Induced Liver Fibrosis in Mice by Reducing Activation and Migration of HSC Induced by Liver Sinusoidal Endothelial Cell-Derived Exosomal SphK1

• Main Authors: Qiannan Ye (Author), Yang Zhou (Author), Changqing Zhao (Author), Lieming Xu (Author), Jian Ping (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Sphingosine kinase 1 (SphK1)/Sphingosine-1-phosphate (S1P)/S1PRs signaling pathway is known to involve the advancement of liver fibrosis. Exosomal SphK1 promotes hepatic stellate cells (HSC) migration. Salidroside (Sal) inhibits liver fibrosis, but its mechanism is yet to be elucidated. This study w...