Interactive Effects of Glucocorticoids and Cytochrome P450 Polymorphisms on the Plasma Trough Concentrations of Voriconazole

• Main Authors: Su-jie Jia (Author), Ke-qin Gao (Author), Pan-hao Huang (Author), Ren Guo (Author), Xiao-cong Zuo (Author), Qing Xia (Author), Shuang-yao Hu (Author), Zhen Yu (Author), Yue-liang Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: To explore the interactive influence of glucocorticoids and cytochrome P450 (CYP450) polymorphisms on voriconazole (VRC) plasma trough concentrations (Cmin) and provide a reliable basis for reasonable application of VRC.Methods: A total of 918 VRC Cmin from 231 patients was collected and quant...