Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles

• Ngā kaituhi matua: Yinan Zhong (Author), Fenghua Meng (Author), Chao Deng (Author), Xinliang Mao (Author), Zhiyuan Zhong (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The chemotherapy of hematological cancers is challenged by its poor selectivity that leads to low therapeutic efficacy and pronounced adverse effects. Here, we report that doxorubicin encapsulated in lipoic acid-crosslinked hyaluronic acid nanoparticles (LACHA-DOX) mediate highly efficacious and tar...