T Cell-Association of Carboxy-Terminal Dendrimers with Different Bound Numbers of Phenylalanine and Their Application to Drug Delivery

• Main Authors: Hiroya Shiba (Author), Tomoka Hirose (Author), Yunshen Fu (Author), Masataka Michigami (Author), Ikuo Fujii (Author), Ikuhiko Nakase (Author), Akikazu Matsumoto (Author), Chie Kojima (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T cells play important roles in various immune reactions, and their activation is necessary for cancer immunotherapy. Previously, we showed that polyamidoamine (PAMAM) dendrimers modified with 1,2-cyclohexanedicarboxylic acid (CHex) and phenylalanine (Phe) underwent effective uptake by various immun...