Disease trajectory of SLE clinical endpoints and covariates affecting disease severity and probability of response: Analysis of pooled patient‐level placebo (Standard‐of‐Care) data to enable model‐informed drug development

• Main Authors: Kosalaram Goteti (Author), Jonathan French (Author), Ramon Garcia (Author), Ying Li (Author), Florence Casset‐Semanaz (Author), Aida Aydemir (Author), Robert Townsend (Author), Cristina Vazquez Mateo (Author), Matthew Studham (Author), Oliver Guenther (Author), Amy Kao (Author), Marc Gastonguay (Author), Pascal Girard (Author), Lisa Benincosa (Author), Karthik Venkatakrishnan (Author)
• Format: Book
• Published: Wiley, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organ systems. Many investigational agents have failed or shown only modest effects when added to standard of care (SoC) therapy in placebo‐controlled trials, and only two therapies have been approved for SLE in...