Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation

• Main Authors: David Roig-Carles (Author), Eduard Willms (Author), Ruud D. Fontijn (Author), Sarai Martinez-Pacheco (Author), Imre Mäger (Author), Helga E. de Vries (Author), Mark Hirst (Author), Basil Sharrack (Author), David K. Male (Author), Cheryl A. Hawkes (Author), Ignacio A. Romero (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Blood-brain barrier (BBB) dysfunction is a key hallmark in the pathology of many neuroinflammatory disorders. Extracellular vesicles (EVs) are lipid membrane-enclosed carriers of molecular cargo that are involved in cell-to-cell communication. Circulating endothelial EVs are increased in the plasma...