Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness

• मुख्य लेखकों: Sean F. Monaghan (लेखक), Debasree Banerjee (लेखक), Chun-Shiang Chung (लेखक), Joanne Lomas-Neira (लेखक), Kamil J. Cygan (लेखक), Christy L. Rhine (लेखक), William G. Fairbrother (लेखक), Daithi S. Heffernan (लेखक), Mitchell M. Levy (लेखक), William G. Cioffi (लेखक), Alfred Ayala (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2018-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiologic alterations. Immune checkpoint inhibitors, such as B and T Lymphocyt...