Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness

• Hoofdauteurs: Sean F. Monaghan (Auteur), Debasree Banerjee (Auteur), Chun-Shiang Chung (Auteur), Joanne Lomas-Neira (Auteur), Kamil J. Cygan (Auteur), Christy L. Rhine (Auteur), William G. Fairbrother (Auteur), Daithi S. Heffernan (Auteur), Mitchell M. Levy (Auteur), William G. Cioffi (Auteur), Alfred Ayala (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2018-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiologic alterations. Immune checkpoint inhibitors, such as B and T Lymphocyt...