Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness

• Main Authors: Sean F. Monaghan (Author), Debasree Banerjee (Author), Chun-Shiang Chung (Author), Joanne Lomas-Neira (Author), Kamil J. Cygan (Author), Christy L. Rhine (Author), William G. Fairbrother (Author), Daithi S. Heffernan (Author), Mitchell M. Levy (Author), William G. Cioffi (Author), Alfred Ayala (Author)
• Format: Book
• Published: BMC, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiologic alterations. Immune checkpoint inhibitors, such as B and T Lymphocyt...