Case report: Emergence of dolutegravir resistance in a patient on second-line antiretroviral therapy

• Main Authors: Kairoonisha Mahomed (Author), Carole L. Wallis (Author), Liezl Dunn (Author), Shavani Maharaj (Author), Gary Maartens (Author), Graeme Meintjes (Author)
• Format: Book
• Published: AOSIS, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The integrase strand transfer inhibitor dolutegravir (DTG) has a high genetic barrier to resistance. Only rare cases of resistance to DTG have been reported when it is used as a component of antiretroviral therapy regimens in treatment-experienced patients unless there was prior use of...