Sulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: a possible candidate for clinical application.

• Main Authors: Koji Ichiyama (Author), Sindhoora Bhargavi Gopala Reddy (Author), Li Feng Zhang (Author), Wei Xin Chin (Author), Tegshi Muschin (Author), Lars Heinig (Author), Youichi Suzuki (Author), Haraprasad Nanjundappa (Author), Yoshiyuki Yoshinaka (Author), Akihide Ryo (Author), Nobuo Nomura (Author), Eng Eong Ooi (Author), Subhash G Vasudevan (Author), Takashi Yoshida (Author), Naoki Yamamoto (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Curdlan sulfate (CRDS), a sulfated 1→3-β-D glucan, previously shown to be a potent HIV entry inhibitor, is characterized in this study as a potent inhibitor of the Dengue virus (DENV). CRDS was identified by in silico blind docking studies to exhibit binding potential to the envelope (E) protein of...