Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD)

• Main Authors: Ozan S. Kumru (Author), Sakshi Bajoria (Author), Kawaljit Kaur (Author), John M. Hickey (Author), Greta Van Slyke (Author), Jennifer Doering (Author), Katherine Berman (Author), Charles Richardson (Author), Hans Lien (Author), Harry Kleanthous (Author), Nicholas J. Mantis (Author), Sangeeta B. Joshi (Author), David B. Volkin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTSecond-generation COVID-19 vaccines with improved immunogenicity (e.g., breadth, duration) and availability (e.g., lower costs, refrigerator stable) are needed to enhance global coverage. In this work, we formulated a clinical-stage SARS-CoV-2 receptor-binding domain (RBD) virus-like particl...