Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events

• المؤلفون الرئيسيون: Howard M. Johnson (مؤلف), Chulbul M. Ahmed (مؤلف)
• التنسيق: كتاب
• منشور في: Hindawi Limited, 2016-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The canonical model of cytokine signaling via the JAK/STAT pathway dominates our view of signal transduction but provides no insight into the significance of the simultaneous presence of activated JAKs and STATs in the nucleus of cells treated with cytokines. Such a mechanistic shortcoming challenge...