Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet

• Main Authors: Markus Mühlemann (Author), Daniela Zdzieblo (Author), Alexandra Friedrich (Author), Constantin Berger (Author), Christoph Otto (Author), Heike Walles (Author), Hermann Koepsell (Author), Marco Metzger (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Glycemic control by medical treatment represents one therapeutic strategy for diabetic patients. The Na+-d-glucose cotransporter 1 (SGLT1) is currently of high interest in this context. SGLT1 is known to mediate glucose absorption and incretin secretion in the small intestine. Recently,...