Study of the effect of anxiolytic GML-1 on the activity of cytochrome CYP2C9 and CYP1A2 isoforms

• Egile Nagusiak: O. G. Gribakina (Egilea), R. V. Shevchenko (Egilea), P. O. Bochkov (Egilea), A. A. Novitskiy (Egilea), A. A. Litvin (Egilea), G. B. Kolyvanov (Egilea), V. P. Zherdev (Egilea)
• Formatua: Liburua
• Argitaratua: LLC "Publisher OKI", 2019-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Resume. Effects of GML-1 compound on activity of isoforms CYP2C9 and CYP1A2 of cytochrome P450 using marker drugs losartane and caffeine in experiments on rats were studied. GML-1 in a dose 10 mg/kg of 10 times higher than the maximum effective anxiolytic dose 1 mg / kg (intraperitoneal administrati...