Design, synthesis and evaluation of 18F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging

• Main Authors: Zhengxing Zhang (Author), Joseph Lau (Author), Chengcheng Zhang (Author), Nadine Colpo (Author), Alessio Nocentini (Author), Claudiu T. Supuran (Author), François Bénard (Author), Kuo-Shyan Lin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic anhydrase IX (CA-IX) is a marker for tumor hypoxia, and its expression is negatively correlated with patient survival. CA-IX represents a potential target for eliminating hypoxic cancers. We synthesized fluorinated cationic sulfonamide inhibitors 1-3 designed to target CA-IX. The binding af...