Biological function molecular pathways and druggability of DNMT2/TRDMT1

• Main Authors: Huari Li (Author), Huiru Liu (Author), Daiyun Zhu (Author), Chengli Dou (Author), Baocai Gang (Author), Mengjie Zhang (Author), Ziyu Wan (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

5-methylcytosine (m5C) is among the most common epigenetic modification in DNA and RNA molecules, and plays an important role in the animal development and disease pathogenesis. Interestingly, unlike other m5C DNA methyltransferases (DNMTs), DNMT2/TRDMT1 has the double-substrate specificity and adop...