Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions

• Main Authors: Deepali Gupta (Author), Anna M. Patterson (Author), Sherri Osborne-Lawrence (Author), Angie L. Bookout (Author), Salil Varshney (Author), Kripa Shankar (Author), Omprakash Singh (Author), Nathan P. Metzger (Author), Corine P. Richard (Author), Steven C. Wyler (Author), Joel K. Elmquist (Author), Jeffrey M. Zigman (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor). GHSR is distributed in several brain regions and some peripheral cell-types including pituitary somatotrophs. The objecti...