Optimisation and Validation of a High Throughput Screening Compatible Assay to Identify Inhibitors of the Plasma Membrane Calcium ATPase Pump - a Novel Therapeutic Target for Contraception and Malaria

• Main Authors: Tamer M A Mohamed (Author), Simon A Zakeri (Author), Florence Baudoin (Author), Markus Wolf (Author), Delvac Oceandy (Author), Elizabeth J Cartwright (Author), Sheraz Gul (Author), Ludwig Neyses (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. ATPases, which constitute a major category of ion transporters in the human body, have a variety of significant biological and pathological roles. However, the lack of high throughput assays for ATPases has significantly limited drug discovery in this area. We have recently found that the g...