Optimisation and Validation of a High Throughput Screening Compatible Assay to Identify Inhibitors of the Plasma Membrane Calcium ATPase Pump - a Novel Therapeutic Target for Contraception and Malaria

• Hauptverfasser: Tamer M A Mohamed (Verfasst von), Simon A Zakeri (Verfasst von), Florence Baudoin (Verfasst von), Markus Wolf (Verfasst von), Delvac Oceandy (Verfasst von), Elizabeth J Cartwright (Verfasst von), Sheraz Gul (Verfasst von), Ludwig Neyses (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2013-05-01T00:00:00Z.
• Schlagworte: article
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Purpose. ATPases, which constitute a major category of ion transporters in the human body, have a variety of significant biological and pathological roles. However, the lack of high throughput assays for ATPases has significantly limited drug discovery in this area. We have recently found that the g...