Intra-Domain Cysteines (IDC), a New Strategy for the Development of Original Antibody Fragment-Drug Conjugates (FDCs)

• Main Authors: Louis Jolivet (Author), Imène Ait Mohamed Amar (Author), Catherine Horiot (Author), Fanny Boursin (Author), Cyril Colas (Author), Stéphanie Letast (Author), Caroline Denevault-Sabourin (Author), Emilie Allard-Vannier (Author), Nicolas Joubert (Author), Nicolas Aubrey (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibody-drug conjugates (ADCs) derived from a full immunoglobulin-G (IgG) are associated with suboptimal solid-tumor penetration and Fc-mediated toxicities. Antibody fragment-drug conjugates (FDCs) could be an alternative. Nevertheless, innovative solutions are needed to implant cysteines as conjug...