Nanoscale coordination polymer Fe-DMY downregulating Poldip2-Nox4-H2O2 pathway and alleviating diabetic retinopathy

• Main Authors: Si-Yu Gui (Author), Xin-Chen Wang (Author), Zhi-Hao Huang (Author), Mei-Mei Li (Author), Jia-Hao Wang (Author), Si-Yin Gui (Author), Gan-Hua Zhang (Author), Yao Lu (Author), Li-Ming Tao (Author), Hai-Sheng Qian (Author), Zheng-Xuan Jiang (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes and the leading cause of blindness and severe visual impairment in adults. The high levels of glucose trigger multiple intracellular oxidative stress pathways, such as POLDIP2, resulting in excessive reactive oxygen spec...