Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile

Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile

Inappropriate expression of histone deacetylase (HDAC-6) and deregulation of the phosphatidylinositol 3-kinase (PI3K) signalling pathway are common aberrations observed in cancers. LASSBio-2208, has been previously described as a dual inhibitor in the nanomolar range of HDAC-6 and PI3Kα and is three...

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Main Authors: Raysa Magali Pillpe-Meza (Author), Wesley Leandro Gouveia (Author), Gisele Barbosa (Author), Carlos A. M. Fraga (Author), Eliezer J. Barreiro (Author), Lidia Moreira Lima (Author)
Format: Book
Published: MDPI AG, 2024-03-01T00:00:00Z.
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