Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile

• المؤلفون الرئيسيون: Raysa Magali Pillpe-Meza (مؤلف), Wesley Leandro Gouveia (مؤلف), Gisele Barbosa (مؤلف), Carlos A. M. Fraga (مؤلف), Eliezer J. Barreiro (مؤلف), Lidia Moreira Lima (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2024-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Inappropriate expression of histone deacetylase (HDAC-6) and deregulation of the phosphatidylinositol 3-kinase (PI3K) signalling pathway are common aberrations observed in cancers. LASSBio-2208, has been previously described as a dual inhibitor in the nanomolar range of HDAC-6 and PI3Kα and is three...