Massively Parallel Sequencingof the Filaggrin Gene Reveals an Association Between FLG Loss-of-function Mutations and Leprosy

• Main Authors: Wenhao Shi (Author), Zihao Mi (Author), Zhenzhen Wang (Author), Huimin Zhang (Author), Na Wang (Author), Zhe Wang (Author), Bowen Zhang (Author), Qianqian Xia (Author), Yueqian Yu (Author), Gongqi Yu (Author), Lele Sun (Author), Xian Fu (Author), Chuan Wang (Author), Hong Liu (Author), Furen Zhang (Author)
• Format: Book
• Published: Medical Journals Sweden, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Filaggrin, encoded by the FLG gene, plays a crucial role in the barrier function of epidermis, but the association between FLG loss-of-function mutations and infectious skin diseases has not been systematically studied. FLG coding sequences from 945 patients with leprosy and 916 healthy controls wer...