Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart

• Main Authors: Giannoula Lakka Klement (Author), David eGoukassian (Author), Lynn eHlatky (Author), Joseph eCarrozza (Author), James P. Morgan (Author), Xinhua eYan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The HER2-PI3K pathway is the one of the most mutated pathways in cancer. Several drugs targeting the major kinases of this pathway have been approved by the Food and Drug Administration and many are being tested in clinical trials for the treatment of various cancers. However, the HER2-PI3K pathway...