Response to trametinib, hydroxychloroquine, and bevacizumab in a young woman with NRAS-mutated metastatic intrahepatic cholangiocarcinoma: a case report

• Main Authors: Aram A. Musaelyan (Author), Ekaterina M. Anokhina (Author), Alina I. Turdubaeva (Author), Natalia V. Mitiushkina (Author), Anastasia N. Ershova (Author), Anna D. Shestakova (Author), Aigul R. Venina (Author), Evgeny N. Imyanitov (Author), Sergey V. Orlov (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Systemic chemotherapy is the main treatment option for patients with advanced intrahepatic cholangiocarcinoma (iCCA), however, its efficacy is limited. Herein, we report a young patient with NRAS-mutated chemoresistant metastatic iCCA, who received second-line therapy with a combination of trametini...