Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study

• Main Authors: Maral Mokhtari (Author), Farzaneh Mostanbet (Author), Saideh Nekooee Fard (Author), Golsa Shekarkhar (Author), Mozhdeh Sepaskhah (Author), Maryam Sadat Sadati (Author)
• Format: Book
• Published: Iranian Society of Pathology, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background & Objective:  Thiopurine drugs are considered as a treatment modality in various autoimmune disorders including pemphigus vulgaris (PV). These drugs are metabolized by an enzyme "Thiopurine S-methyl transferase" (TPMT). Various variants of this enzyme may have decreased acti...