Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study

• المؤلفون الرئيسيون: Maral Mokhtari (مؤلف), Farzaneh Mostanbet (مؤلف), Saideh Nekooee Fard (مؤلف), Golsa Shekarkhar (مؤلف), Mozhdeh Sepaskhah (مؤلف), Maryam Sadat Sadati (مؤلف)
• التنسيق: كتاب
• منشور في: Iranian Society of Pathology, 2020-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background & Objective:  Thiopurine drugs are considered as a treatment modality in various autoimmune disorders including pemphigus vulgaris (PV). These drugs are metabolized by an enzyme "Thiopurine S-methyl transferase" (TPMT). Various variants of this enzyme may have decreased acti...