Role of ROS in Aβ42 Mediated Activation of Cerebral Endothelial Cells

• Main Authors: Andrey Tsoy (Author), Bauyrzhan Umbayev (Author), Tamara Shalakhmetova (Author), Sholpan Askarova (Author)
• Format: Book
• Published: University Library System, University of Pittsburgh, 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. There is substantial evidence that the deposition of aggregated amyloid-beta peptide (Aβ) in brain parenchyma and brain vessels is the main cause of neuronal dysfunction and death in Alzheimer's disease (AD). Aβ exhibits multiple cytotoxic effects on neurons and glial cells and ca...