Phenolic Compounds Reduce the Fat Content in <i>Caenorhabditis elegans</i> by Affecting Lipogenesis, Lipolysis, and Different Stress Responses

• Główni autorzy: Paula Aranaz (Autor), David Navarro-Herrera (Autor), María Zabala (Autor), Ana Romo-Hualde (Autor), Miguel López-Yoldi (Autor), José Luis Vizmanos (Autor), Fermín I. Milagro (Autor), Carlos J. González-Navarro (Autor)
• Format: Książka
• Wydane: MDPI AG, 2020-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Streszczenie

Supplementation with bioactive compounds capable of regulating energy homeostasis is a promising strategy to manage obesity. Here, we have screened the ability of different phenolic compounds (myricetin, kaempferol, naringin, hesperidin, apigenin, luteolin, resveratrol, curcumin, and epicatechin) and phenolic acids (<i>p</i>-coumaric, ellagic, ferulic, gallic, and vanillic acids) regulating <i>C. elegans</i> fat accumulation. Resveratrol exhibited the strongest lipid-reducing activity, which was accompanied by the improvement of lifespan, oxidative stress, and aging, without affecting worm development. Whole-genome expression microarrays demonstrated that resveratrol affected fat mobilization, fatty acid metabolism, and unfolded protein response of the endoplasmic reticulum (UPR^ER), mimicking the response to calorie restriction. Apigenin induced the oxidative stress response and lipid mobilization, while vanillic acid affected the unfolded-protein response in ER. In summary, our data demonstrates that phenolic compounds exert a lipid-reducing activity in <i>C. elegans</i> through different biological processes and signaling pathways, including those related with lipid mobilization and fatty acid metabolism, oxidative stress, aging, and UPR-ER response. These findings open the door to the possibility of combining them in order to achieve complementary activity against obesity-related disorders.

Deskrypcja

10.3390/ph13110355
1424-8247