Bactericidal Immunity to Salmonella in Africans and Mechanisms Causing Its Failure in HIV Infection.

• Main Authors: Yun Shan Goh (Author), Francesca Necchi (Author), Colette M O'Shaughnessy (Author), Francesca Micoli (Author), Massimiliano Gavini (Author), Stephen P Young (Author), Chisomo L Msefula (Author), Esther N Gondwe (Author), Wilson L Mandala (Author), Melita A Gordon (Author), Allan J Saul (Author), Calman A MacLennan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Nontyphoidal strains of Salmonella are a leading cause of death among HIV-infected Africans. Antibody-induced complement-mediated killing protects healthy Africans against Salmonella, but increased levels of anti-lipopolysaccharide (LPS) antibodies in some HIV-infected African adults bloc...