Microglial roles in Alzheimer's disease: An agent‐based model to elucidate microglial spatiotemporal response to beta‐amyloid

• Main Authors: Catherine Weathered (Author), Sophia Bardehle (Author), Choya Yoon (Author), Niyanta Kumar (Author), Cheryl E. G. Leyns (Author), Matthew E. Kennedy (Author), Peter Bloomingdale (Author), Elsje Pienaar (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Alzheimer's disease (AD) is characterized by beta‐amyloid (Aβ) plaques in the brain and widespread neuronal damage. Because of the high drug attrition rates in AD, there is increased interest in characterizing neuroimmune responses to Aβ plaques. In response to AD pathology, microglia...