Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA alterations underlie the development of sarcopenia

• Main Authors: Sammy Kimoloi (Author), Ayesha Sen (Author), Stefan Guenther (Author), Thomas Braun (Author), Tobias Brügmann (Author), Philipp Sasse (Author), Rudolf J. Wiesner (Author), David Pla‐Martín (Author), Olivier R. Baris (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mitochondrial dysfunction caused by mitochondrial (mtDNA) deletions have been associated with skeletal muscle atrophy and myofibre loss. However, whether such defects occurring in myofibres cause sarcopenia is unclear. Also, the contribution of mtDNA alterations in muscle stem ce...