Redox modifications of cysteine residues regulate the cytokine activity of HMGB1

• Main Authors: Huan Yang (Author), Peter Lundbäck (Author), Lars Ottosson (Author), Helena Erlandsson-Harris (Author), Emilie Venereau (Author), Marco E. Bianchi (Author), Yousef Al-Abed (Author), Ulf Andersson (Author), Kevin J. Tracey (Author)
• Format: Book
• Published: BMC, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is passively released during cell death and secreted by activated cells of many lineages. HMGB1 contains three conserved redox-sensitive cysteine residues: cysteines in po...