A Review of Mathematics Determining Solute Uptake at the Blood-Brain Barrier in Normal and Pathological Conditions

• Главные авторы: Samuel A. Sprowls (Автор), Pushkar Saralkar (Автор), Tasneem Arsiwala (Автор), Christopher E. Adkins (Автор), Kathryn E. Blethen (Автор), Vincenzo J. Pizzuti (Автор), Neal Shah (Автор), Ross Fladeland (Автор), Paul R. Lockman (Автор)
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• Опубликовано: MDPI AG, 2021-05-01T00:00:00Z.
• Предметы: article
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The blood-brain barrier (BBB) limits movement of solutes from the lumen of the brain microvascular capillary system into the parenchyma. The unidirectional transfer constant, <i>K_in</i>, is the rate at which transport across the BBB occurs for individual molecules....