Cinnamic acid derivatives: inhibitory activity against Escherichia coli β-glucuronidase and structure-activity relationships

• Main Authors: Xing-Nuo Li (Author), Lu-Xia Hua (Author), Tao-Shun Zhou (Author), Ke-Bo Wang (Author), Yuan-Yuan Wu (Author), Mahmoud Emam (Author), Xiao-Ze Bao (Author), Jun Chen (Author), Bin Wei (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gut microbial β-glucuronidase (GUS) is a potential therapeutic target to reduce gastrointestinal toxicity caused by irinotecan. In this study, the inhibitory effects of 17 natural cinnamic acid derivatives on Escherichia coli GUS (EcGUS) were characterised. Seven compounds, including caffeic acid et...