Pimozide Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species

• Main Authors: Ukjin Kim (Author), C-Yoon Kim (Author), Ji Min Lee (Author), Bokyeong Ryu (Author), Jin Kim (Author), Changsoo Shin (Author), Jae-Hak Park (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The United States Food and Drug Administration-approved antipsychotic drug, pimozide, has anticancer activities. However, the role of reactive oxygen species (ROS) in its effect on prostate cancer is not well-known. We examined cell proliferation, colony formation, migration, ROS production, and the...