Periostin-Binding DNA Aptamer Treatment Ameliorates Peritoneal Dialysis-Induced Peritoneal Fibrosis

• Main Authors: Bo Young Nam (Author), Jung Tak Park (Author), Young Eun Kwon (Author), Jung Pyo Lee (Author), Jong Ha Jung (Author), Youndong Kim (Author), Seonghun Kim (Author), Jimin Park (Author), Jae Eun Um (Author), Meiyan Wu (Author), Seung Hyeok Han (Author), Tae-Hyun Yoo (Author), Shin-Wook Kang (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peritoneal fibrosis is a major complication in peritoneal dialysis (PD) patients, which leads to dialysis discontinuation. Periostin, increased by transforming growth factor β1 (TGF-β1) stimulation, induces the expression of extracellular matrix (ECM) genes. Aberrant periostin expression has been de...